Marcello Moccia

背景： 氧化应激是多发性硬化症（MS）病理学的驱动力。我们评估了辅酶Q10（COQ10）对实验室M的影响arkers of oxidative stress and inflammation, and on MS clinical severity.

Methods: We included 60 relapsing-remitting patients with MS treated with interferon beta1a 44μg (IFN-β1a) with CoQ10 for 3 months, and with IFN-β1a 44μg alone for 3 more months （在开放标签的跨界设计中）。 At baseline and at the 3 and 6-month visits, we measured markers of scavenging activity, oxidative damage and inflammation in the peripheral blood, and collected data on disease severity.

Results: After 3 months, CoQ10 supplementation was associated with improved scavenging activity (as mediated by uric acid),减少了细胞内活性氧的产生，氧化性DNA损伤减少，并朝着外周血（具有较高白介素（IL）-4和IL-13的较高的抗炎环境以及较低的eotaxin，粒细胞粒细胞刺激性刺激（GM-CS）（GM-CM-CS）转移到更抗炎的环境（IL）-4和IL-13（IL）-4和IL-13。F), hepatocyte growth factor (HGF), interferon (IFN)-γ, IL-1α, IL-2R, IL-9, IL-17F, macrophage inflammatory proteins (MIP)-1α, regulated on activation-normal T cell expressed and secreted (RANTES), tumor necrosis factor (TNF)-α, and vascular endothelial growth factor (VEGF). Also, CoQ10 supplementation was associated with lower Expanded DisabilityStatus Scale, fatigue severity scale, Becks depression inventory, and the visual analogue scale for pain.

Conclusions: CoQ10 supplementation improved scavenging activity, reduced oxidative damage, and induced a shift towards a more anti-inflammatory环境中，在用44μgIFN-β1A44μg治疗的复发的MS患者的外周血中。可能会发现可能的临床效果，但值得在更长的随访中得到确认。