aruna qian

目标： 急性肝损伤（ALF）是许多严重肝病的潜在因素。四氯化碳（CCL）是一种可能诱导Alf的环境有毒物质。我们探讨了PO在调节中的重要性CCL引起的肝损伤期间动物模型和培养的肝细胞的炎症功能。检查了转氨酶活性和炎症因子的肝水平。通过RT-PCR和Western印迹分析测量了S100A8和S100A9的基因和蛋白质表达。同时，PO的功效通过HEPG2细胞认证。 The transaminase activities, inflammatory factors, and the protein expression of S100A8 and S100A9 were also detected.

RESULTS: Animal tests showed that pretreatment with PO reduced the liver pathological tissue damage and the serum levels of ALT, AST, ALT and LDH, as well as reducing the CCL诱导的肝损伤小鼠中促炎性细胞因子（IL-1β，IL-6，TNF-α）分泌。同时，用PO预处理的HEPG2细胞表现出显着降低在ALT和AST的活动中。此外，PO导致促炎标记物S100A8，S100A9基因和蛋白质表达的明显下调，这完全证明了急性肝损伤。促炎性细胞因子释放，表明控制疾病具有潜在的临床作用。