Xiaojing Lin

BACKGROUND: Heat stroke-induced mortality is在全球范围内上升。因此，预防性和/或热中风的治疗方式的设计迫切需要。普通的植物衍生的类黄酮表现出强烈的抗氧化剂和抗炎活性。但是，它的影响中风中的s仍然未知。 The study aimed to investigate the cardioprotective effects of myricetin on heat stroke induced acute myocardial injury as well as lethality in rats and to explore the underlying mechanisms.

METHODS: Myocardial injury was induced by subjecting the anesthetized rats to a high ambient temperature of 43°C持续70分钟。在热应激开始前一周，每天给大鼠一次，每天给大鼠一次，每天给大鼠一次胃肠内剂量（5-25 mg/kg体重）。热休克蛋白72抗体在热应激开始前24小时内对大鼠进行腹膜内。心肌损伤的严重程度是通过确定心肌损伤评分，心肌损伤指标，心肌氧化和炎症因素来估计的。蛋白质印迹分析用于热休克蛋白（HSP）的心脏表达72。

结果： 有意义（p <0.05）上调长期给药典型的HSP-72与高温，低血压，心脏炎症和氧化损伤和致死性的显着降低（P <0.05）相吻合。 Inhibition of HSP-72 showed a significant (P<0.05) reversal in the cardiaprotection as well as survival.

CONCLUSIONS: Our results indicate that myricetin diminishes myocardial injury as well as lethality in heat stroke by up-regulating HSP-72 and show promise as a novel预防中风治疗。