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Clinical effects of wasabi extract containing 6-MSITC on myalgic脑脊髓炎/慢性疲劳综合征：一项开放标签试验。

Biopsychosoc Med。 2022年12月12日; 16（1）：26。 EPUB 2022 12月12日。PMID： 36510244 Lkhagvasuren，Mutsuhiro Nakao，Ryota Nakajima，Masanobu Kanou，ryuji hiramatsu，yo-ichi nabeshima

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METHODS: Fifteen patients (3 males, 12 females, 20-58 years old) were orally administered wasabi extract (9.6 mg of 6-mSITC/天）持续12周。 The following parameters and test results were compared pre- and post-treatment: performance status (PS), self-rating questionnaires, pressure pain threshold (PPT) on the occiput, Trail Making test-A (TMT-A), and hemodynamic patterns determined by an active standing test.

RESULTS: After treatment with 6-MSITC，PS显着改善（P = 0.001）。尽管在11个项目的Chalder疲劳量表（CFS-11）和Numerica上得分l rating scale (NRS) of fatigue did not show significant changes, subjective symptoms improved significantly, including headache frequency (4.1 to 3.0 times/week, p = 0.001) and myalgia (4.1 to 2.4 times/week, p = 0.019), NRS brain fog scores (5.7 to 4.5, p = 0.011), difficulty finding appropriate words (4.8 to 3.7, p = 0.015), photophobia （4.8至3.5，p = 0.008）和情绪状态活力得分（46.9至50.0，p = 0.045）。右枕骨的PPT（17.3至21.3 kPa，p = 0.01）和TMT-A评分（53.0至38.1 s，p = 0.007）也发生了变化，表明降低了疼痛敏感性，并提高了认知功能。由常规测试确定的定位模式并未显示出显着的变化。没有严重的不良反应。

结论： 这项研究表明，6-MSITC改善了PS以及主观症状以及诸如ME/CFS患者的疼痛和认知功能障碍和心理效率等主观症状。它还改善了这些患者的认知表现和增加的疼痛阈值。 6-MSITC可能是一种有希望的治疗选择，特别是用于改善与ME/CFS相关的认知功能障碍。